2. All-trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Acute Promyelocytic Leukemia: All-Trans-Retinoic Acid Era
Acute promyelocytic leukemia (APL) is highly curable with the combination of all retinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypi molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus. We describe the data of nin...
متن کاملThe role of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia.
All-trans-retinoic acid (ATRA) has demonstrated in vivo and in vitro that it could differentiate leukemic cells in acute promyelocytic leukemia (APL). ATRA yields complete remission (CR) rates of approximately 90% in newly diagnosed and first relapsing APL, in APL resistant to one or two courses of chemotherapy, whereas patients in second and subsequent remissions often have only partial remiss...
متن کاملUse of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
Twenty-four patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of these, eight cases had been either nonresponsive or resistant to previous chemotherapy; the other 16 cases were previously untreated. All patients attained complete remission without developing bone marrow hypoplasia. Bone marrow suspension cultures were studied in 15...
متن کاملUse of All-Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Twenty-four patients with acute promyelocytic leukemia (API) were treated with all-trans retinoic acid (45 to 100 mg/m2/day). Of these. eight cases had been either nonresponsive or resistant to previous chemotherapy; the other 1 6 cases were previously untreated. All patients attained complete remission without developing bone marrow hypoplasia. Bone marrow suspension cultures were studied in 1...
متن کاملAll-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.
All-trans retinoic acid (ATRA) can induce complete remission (CR) in most patients with acute promyelocytic leukemia (APL) through in vivo differentiation of APL-blasts. However, it cannot eliminate the leukemic clone and must be used in combination with anthracycline-based chemotherapy. Experience accumulated over the last 10 years has clearly shown that the combination of ATRA and chemotherap...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2007
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.46.1780